Role of Regenerative Medicine in the Treatment of Diseases
Keywords:
Regenerative Medicine , Treatment , Diseases, PathogenesisAbstract
Regenerative medicine is a rapidly advancing field that aims to restore, replace, or regenerate damaged tissues and organs using advanced biomedical techniques. Its potential to revolutionize healthcare by providing innovative solutions for previously incurable or difficult-to-treat medical conditions is immense. The fundamental principle of regenerative medicine lies in harnessing the body's natural healing mechanisms to stimulate tissue repair and regeneration. Stem cell therapy is one approach within this field that holds great promise. Stem cells possess the ability to differentiate into specialized cell types, making them valuable for tissue repair. They have shown encouraging results in treating spinal cord injuries, heart disease, and certain cancers. Tissue engineering is another crucial aspect of regenerative medicine, involving the creation of functional tissue constructs using cells, scaffolds, and growth factors. This approach has successfully regenerated skin, cartilage, bone, and blood vessels. Gene therapy, which aims to correct or replace defective genes, offers potential treatments for genetic disorders and has shown promise in diseases like cystic fibrosis, muscular dystrophy, and cancer. Biomaterials provide a supportive environment for tissue regeneration, acting as scaffolds to guide cell growth and facilitate integration. Regenerative medicine not only addresses diseases and injuries but also offers solutions to organ shortages, immunosuppressive drug dependency, and chronic conditions. Despite challenges in safety, efficacy, manufacturing, and regulation, ongoing research, technological advancements, and collaboration between stakeholders hold the promise of transforming healthcare. In conclusion, regenerative medicine is a multidisciplinary field that strives to restore tissue and organ function through various approaches. It offers hope to patients with previously untreatable conditions and has the potential to significantly impact the future of medicine.
References
Tian S, Liu Q, Gnatovskiy L, Ma PX, Wang Z. Heart regeneration with embryonic cardiac progenitor cells and cardiac tissue engineering. Journal of stem cell and transplantation biology. 2015;1(1).
Bartold PM, Gronthos S, Ivanovski S, Fisher A, Hutmacher DW. Tissue engineered periodontal products. J Periodontal Res. 2016;51(1):1-15.
De Pieri A, Rochev Y, Zeugolis DI. Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast. npj Regenerative Medicine. 2021;6(1):18.
Shahsavari M, Mazreah SA, Shoghi A, Gheysari R. Evaluation of Matrix Metalloproteinases 2 and 9 in Oral Squamous Cell Carcinoma and Verrucous Carcinoma. International Journal of High Risk Behaviors and Addiction. 2022;11(2).
Shahsavari M, Azizi S. Cytological Evaluation of Cellular Atypia in the Oral Mucosa of Active and Passive Cigarette Smokers. Dental Clinical and Experimental Journal.4(1).
Mazreah SA, Shahsavari M, Kalati PA, Mazreah HA. Immunohistochemical evaluation of CD117 in mast cell of aggressive periodontitis. Journal of Indian Society of Periodontology. 2020;24(3):216.
SHaHSaVari M, aZiZi MaZreaH S, arBaBi Kalati P. Expression of mast cell in aggressive periodontitis. Minerva Stomatol. 2020;69(3):127-32.
Shirvani A, Dianat O. Evaluation of irrigant extrusion following the use of different root canal irrigation techniques: A systematic review and meta-analysis. Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc. 2022.
Foglia MJ, Poss KD. Building and re-building the heart by cardiomyocyte proliferation. Development. 2016;143(5):729-40.
Founta K-M, Tourkodimitri M-I, Kanaki Z, Bisti S, Papanayotou C. Development of a Method for the In Vivo Generation of Allogeneic Hearts in Chimeric Mouse Embryos. International Journal of Molecular Sciences. 2023;24(2):1163.
Garbern JC, Lee RT. Cardiac stem cell therapy and the promise of heart regeneration. Cell stem cell. 2013;12(6):689-98.
González-Rosa JM, Mercader N. Cryoinjury as a myocardial infarction model for the study of cardiac regeneration in the zebrafish. Nature protocols. 2012;7(4):782-8.
Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, Gepstein A, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. The Journal of clinical investigation. 2001;108(3):407-14.
Parente V, Balasso S, Pompilio G, Verduci L, Colombo GI, Milano G, et al. Hypoxia/reoxygenation cardiac injury and regeneration in zebrafish adult heart. PloS one. 2013;8(1):e53748.
Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331(6020):1078-80.
Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, et al. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proceedings of the National Academy of Sciences. 2013;110(1):187-92.
Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science. 2002;298(5601):2188-90.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012;485(7400):593-8.
Takeuchi R, Kuruma Y, Sekine H, Dobashi I, Yamato M, Umezu M, et al. In vivo vascularization of cell sheets provided better long‐term tissue survival than injection of cell suspension. Journal of tissue engineering and regenerative medicine. 2016;10(8):700-10.
Wang H, Wisneski A, Imbrie-Moore AM, Paulsen MJ, Wang Z, Xuan Y, et al. Natural cardiac regeneration conserves native biaxial left ventricular biomechanics after myocardial infarction in neonatal rats. Journal of the Mechanical Behavior of Biomedical Materials. 2022;126:105074.
Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, et al. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011;138(16):3421-30.
Xin M, Olson EN, Bassel-Duby R. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nature reviews Molecular cell biology. 2013;14(8):529-41.
Zhang Y, Mignone J, MacLellan WR. Cardiac regeneration and stem cells. Physiological reviews. 2015;95(4):1189-204.
Caras IW, Collins LR, Creasey AA. A Stem Cell Journey in Ophthalmology: From the Bench to the Clinic. Stem Cells Translational Medicine. 2021;10(12):1581-7.
Chen F-M, Wu L-A, Zhang M, Zhang R, Sun H-H. Homing of endogenous stem/progenitor cells for in situ tissue regeneration: promises, strategies, and translational perspectives. Biomaterials. 2011;32(12):3189-209.
Kang SK, Shin IS, Ko MS, Jo JY, Ra JC. Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy. Stem Cells International. 2012;2012:342968.
Nawab K, Bhere D, Bommarito A, Mufti M, Naeem A. Stem cell therapies: a way to promising cures. Cureus. 2019;11(9).
Wan PX, Wang BW, Wang ZC. Importance of the stem cell microenvironment for ophthalmological cell-based therapy. World J Stem Cells. 2015;7(2):448-60.
Bijukumar DR, McGeehan C, Mathew MT. Regenerative Medicine Strategies in Biomedical Implants. Current Osteoporosis Reports. 2018;16(3):236-45.
Chai J, Jin R, Yuan G, Kanter V, Miron RJ, Zhang Y. Effect of Liquid Platelet-rich Fibrin and Platelet-rich Plasma on the Regenerative Potential of Dental Pulp Cells Cultured under Inflammatory Conditions: A Comparative Analysis. J Endod. 2019;45(8):1000-8.
Huang GT, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res. 2009;88(9):792-806.
Song JS, Takimoto K, Jeon M, Vadakekalam J, Ruparel NB, Diogenes A. Decellularized Human Dental Pulp as a Scaffold for Regenerative Endodontics. J Dent Res. 2017;96(6):640-6.
Tanaka J, Mishima K. Application of regenerative medicine to salivary gland hypofunction. Jpn Dent Sci Rev. 2021;57:54-9.
Tsigkou O, Pomerantseva I, Spencer JA, Redondo PA, Hart AR, O'Doherty E, et al. Engineered vascularized bone grafts. Proc Natl Acad Sci U S A. 2010;107(8):3311-6.
Wang J, Wang X, Sun Z, Wang X, Yang H, Shi S, et al. Stem cells from human-exfoliated deciduous teeth can differentiate into dopaminergic neuron-like cells. Stem Cells Dev. 2010;19(9):1375-83.
Zhang M, Jiang F, Zhang X, Wang S, Jin Y, Zhang W, et al. The Effects of Platelet-Derived Growth Factor-BB on Human Dental Pulp Stem Cells Mediated Dentin-Pulp Complex Regeneration. Stem Cells Transl Med. 2017;6(12):2126-34.
Andersen H, Aass AM, Wohlfahrt JC. Porous titanium granules in the treatment of peri-implant osseous defects-a 7-year follow-up study. Int J Implant Dent. 2017;3(1):50-.
Ausenda F, Rasperini G, Acunzo R, Gorbunkova A, Pagni G. New Perspectives in the Use of Biomaterials for Periodontal Regeneration. Materials (Basel). 2019;12(13).
Baldini N, De Sanctis M, Ferrari M. Deproteinized bovine bone in periodontal and implant surgery. Dent Mater. 2011;27(1):61-70.
Bashutski JD, Eber RM, Kinney JS, Benavides E, Maitra S, Braun TM, et al. Teriparatide and osseous regeneration in the oral cavity. N Engl J Med. 2010;363(25):2396-405.
Birang R, Shahabooei M, Mashhadiabbas F, Atabaki M, Naghsh N, Kavosh K, et al. Effect of enamel matrix derivative on bone formation around intraosseous titanium implant: An experimental study in canine model. Dent Res J (Isfahan). 2012;9(6):790-6.
Bozkurt Y, Karayel E. 3D printing technology; methods, biomedical applications, future opportunities and trends. Journal of Materials Research and Technology. 2021;14:1430-50.
Brouwer KM, Lundvig DM, Middelkoop E, Wagener FA, Von den Hoff JW. Mechanical cues in orofacial tissue engineering and regenerative medicine. Wound Repair Regen. 2015;23(3):302-11.
Caffesse RG, Mota LF, Quiñones CR, Morrison EC. Clinical comparison of resorbable and non-resorbable barriers for guided periodontal tissue regeneration. J Clin Periodontol. 1997;24(10):747-52.
Chang PC, Cirelli JA, Jin Q, Seol YJ, Sugai JV, D'Silva NJ, et al. Adenovirus encoding human platelet-derived growth factor-B delivered to alveolar bone defects exhibits safety and biodistribution profiles favorable for clinical use. Hum Gene Ther. 2009;20(5):486-96.
Chatterjee A, Singh N, Saluja M. Gene therapy in periodontics. Journal of Indian Society of Periodontology. 2013;17(2):156-61.
Cheah CW, Al-Namnam NM, Lau MN, Lim GS, Raman R, Fairbairn P, et al. Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next? Materials (Basel). 2021;14(20):6123.
Chia HN, Wu BM. Recent advances in 3D printing of biomaterials. J Biol Eng. 2015;9:4-.
Cortellini P, Tonetti MS. Clinical concepts for regenerative therapy in intrabony defects. Periodontology 2000. 2015;68(1):282-307.
Deliberador TM, Mendes RT, Storrer CL, Giovanini AF, Zielak JC, Lopes TR. Autogenous bone graft combined with buccal fat pad as barrier in treatment of Class II furcation defect: a case report. Bull Tokyo Dent Coll. 2012;53(3):127-32.
Dunn CA, Jin Q, Taba M, Franceschi RT, Bruce Rutherford R, Giannobile WV. BMP gene delivery for alveolar bone engineering at dental implant defects. Molecular Therapy. 2005;11(2):294-9.
Elsalanty ME, Genecov DG. Bone grafts in craniofacial surgery. Craniomaxillofac Trauma Reconstr. 2009;2(3):125-34.
Fan C, Ji Q, Zhang C, Xu S, Sun H, Li Z. TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production. Mol Med Rep. 2019;20(4):3123-30.
Fan L, Wu D. Enamel Matrix Derivatives for Periodontal Regeneration: Recent Developments and Future Perspectives. Journal of Healthcare Engineering. 2022;2022:8661690.
Freitas RM, Spin-Neto R, Marcantonio Junior E, Pereira LA, Wikesjö UM, Susin C. Alveolar ridge and maxillary sinus augmentation using rhBMP-2: a systematic review. Clin Implant Dent Relat Res. 2015;17 Suppl 1:e192-201.
Gamal AY, Mailhot JM. A novel marginal periosteal pedicle graft as an autogenous guided tissue membrane for the treatment of intrabony periodontal defects. J Int Acad Periodontol. 2008;10(4):106-17.
Gault P, Black A, Romette J-L, Fuente F, Schroeder K, Thillou F, et al. Tissue-engineered ligament: implant constructs for tooth replacement. Journal of Clinical Periodontology. 2010;37(8):750-8.
Gillman CE, Jayasuriya AC. FDA-approved bone grafts and bone graft substitute devices in bone regeneration. Materials Science and Engineering: C. 2021;130:112466.
Green DW, Lee J-S, Jung H-S. Small-Scale Fabrication of Biomimetic Structures for Periodontal Regeneration. Frontiers in Physiology. 2016;7.
Gul M, Arif A, Ghafoor R. Role of three-dimensional printing in periodontal regeneration and repair: Literature review. Journal of Indian Society of Periodontology. 2019;23(6):504-10.
Gulati M, Anand V, Govila V, Jain N, Rastogi P, Bahuguna R, et al. Periodontio-integrated implants: A revolutionary concept. Dent Res J (Isfahan). 2014;11(2):154-62.
Hägi TT, Laugisch O, Ivanovic A, Sculean A. Regenerative periodontal therapy. Quintessence international (Berlin, Germany : 1985). 2014;45(3):185-92.
Holick MF. PTH (1-34): a novel anabolic drug for the treatment of osteoporosis. South Med J. 2005;98(11):1114-7.
Iorio-Siciliano V, Blasi A, Stratul SI, Ramaglia L, Octavia V, Salvi GE, et al. Healing of periodontal suprabony defects following treatment with open flap debridement with or without an enamel matrix derivative: A randomized controlled clinical study. Clin Oral Investig. 2021;25(3):1019-27.
Isehed C, Svenson B, Lundberg P, Holmlund A. Surgical treatment of peri-implantitis using enamel matrix derivative, an RCT: 3- and 5-year follow-up. J Clin Periodontol. 2018;45(6):744-53.
Iwata T, Yamato M, Washio K, Ando T, Okano T, Ishikawa I. Cell Sheets for Periodontal Tissue Engineering. Current Oral Health Reports. 2015;2(4):252-6.
Jimbo R, Tovar N, Janal MN, Mousa R, Marin C, Yoo D, et al. The effect of brain-derived neurotrophic factor on periodontal furcation defects. PLoS One. 2014;9(1):e84845.
Jin Q, Anusaksathien O, Webb SA, Printz MA, Giannobile WV. Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors. Mol Ther. 2004;9(4):519-26.
Jin QM, Zhao M, Webb SA, Berry JE, Somerman MJ, Giannobile WV. Cementum engineering with three-dimensional polymer scaffolds. J Biomed Mater Res A. 2003;67(1):54-60.
Kapogianni E, Alkildani S, Radenkovic M, Xiong X, Krastev R, Stöwe I, et al. The Early Fragmentation of a Bovine Dermis-Derived Collagen Barrier Membrane Contributes to Transmembraneous Vascularization—A Possible Paradigm Shift for Guided Bone Regeneration. Membranes. 2021;11(3):185.
Kiany F, Moloudi F. Amnion membrane as a novel barrier in the treatment of intrabony defects: a controlled clinical trial. Int J Oral Maxillofac Implants. 2015;30(3):639-47.
Kim T-I, Chung C-P, Heo M-S, Park Y-J, Rhee S-H. Periodontal regeneration capacity of equine particulate bone in canine alveolar bone defects. J Periodontal Implant Sci. 2010;40(5):220-6.
Kim TK, Eberwine JH. Mammalian cell transfection: the present and the future. Anal Bioanal Chem. 2010;397(8):3173-8.
Kim YK, Ku JK. Guided bone regeneration. J Korean Assoc Oral Maxillofac Surg. 2020;46(5):361-6.
Kitamura M, Akamatsu M, Machigashira M, Hara Y, Sakagami R, Hirofuji T, et al. FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial. J Dent Res. 2011;90(1):35-40.
Krasilnikova OA, Baranovskii DS, Lyundup AV, Shegay PV, Kaprin AD, Klabukov ID. Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action. Stem Cell Rev Rep. 2022;18(6):1974-85.
Larsson L, Decker AM, Nibali L, Pilipchuk SP, Berglundh T, Giannobile WV. Regenerative Medicine for Periodontal and Peri-implant Diseases. J Dent Res. 2016;95(3):255-66.
Laurell L, Gottlow J. Guided tissue regeneration update. Int Dent J. 1998;48(4):386-98.
Lee C-K, Koo K-T, Kim T-I, Seol Y-J, Lee Y-M, Rhyu I-C, et al. Biological effects of a porcine-derived collagen membrane on intrabony defects. J Periodontal Implant Sci. 2010;40(5):232-8.
Lee CH, Hajibandeh J, Suzuki T, Fan A, Shang P, Mao JJ. Three-dimensional printed multiphase scaffolds for regeneration of periodontium complex. Tissue Eng Part A. 2014;20(7-8):1342-51.
Lee J, Wikesjö UM. Growth/differentiation factor-5: pre-clinical and clinical evaluations of periodontal regeneration and alveolar augmentation--review. J Clin Periodontol. 2014;41(8):797-805.
Lee JH, Um S, Jang JH, Seo BM. Effects of VEGF and FGF-2 on proliferation and differentiation of human periodontal ligament stem cells. Cell Tissue Res. 2012;348(3):475-84.
Liang Y, Luan X, Liu X. Recent advances in periodontal regeneration: A biomaterial perspective. Bioactive Materials. 2020;5(2):297-308.
Lin Z, Rios HF, Cochran DL. Emerging regenerative approaches for periodontal reconstruction: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015;86(2 Suppl):S134-52.
Lu CH, Chang YH, Lin SY, Li KC, Hu YC. Recent progresses in gene delivery-based bone tissue engineering. Biotechnol Adv. 2013;31(8):1695-706.
Mason C, Dunnill P. A brief definition of regenerative medicine. Regen Med. 2008;3(1):1-5.
Matichescu A, Ardelean LC, Rusu LC, Craciun D, Bratu EA, Babucea M, et al. Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration-A Review. Materials (Basel). 2020;13(22).
Miliotou AN, Foltopoulou PF, Ingendoh-Tsakmakidis A, Tsiftsoglou AS, Vizirianakis IS, Pappas IS, et al. Protein Transduction Domain-Mediated Delivery of Recombinant Proteins and In Vitro Transcribed mRNAs for Protein Replacement Therapy of Human Severe Genetic Mitochondrial Disorders: The Case of Sco2 Deficiency. Pharmaceutics. 2023;15(1):286.
Naidoo J, Young D. Gene regulation systems for gene therapy applications in the central nervous system. Neurol Res Int. 2012;2012:595410-.
Nuñez J, Vignoletti F, Caffesse RG, Sanz M. Cellular therapy in periodontal regeneration. Periodontology 2000. 2019;79(1):107-16.
Obregon F, Vaquette C, Ivanovski S, Hutmacher DW, Bertassoni LE. Three-Dimensional Bioprinting for Regenerative Dentistry and Craniofacial Tissue Engineering. J Dent Res. 2015;94(9 Suppl):143s-52s.
Oshima M, Inoue K, Nakajima K, Tachikawa T, Yamazaki H, Isobe T, et al. Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy. Sci Rep. 2014;4:6044-.
Parashis AO, Polychronopoulou A, Tsiklakis K, Tatakis DN. Enamel matrix derivative in intrabony defects: prognostic parameters of clinical and radiographic treatment outcomes. J Periodontol. 2012;83(11):1346-52.
Ramseier CA, Abramson ZR, Jin Q, Giannobile WV. Gene therapeutics for periodontal regenerative medicine. Dental clinics of North America. 2006;50(2):245-ix.
Rao SM, Ugale GM, Warad SB. Bone morphogenetic proteins: periodontal regeneration. N Am J Med Sci. 2013;5(3):161-8.
Rasia-dal Polo M, Poli P-P, Rancitelli D, Beretta M, Maiorana C. Alveolar ridge reconstruction with titanium meshes: a systematic review of the literature. Med Oral Patol Oral Cir Bucal. 2014;19(6):e639-e46.
Rasperini G, Pilipchuk SP, Flanagan CL, Park CH, Pagni G, Hollister SJ, et al. 3D-printed Bioresorbable Scaffold for Periodontal Repair. J Dent Res. 2015;94(9 Suppl):153s-7s.
Sakkas A, Wilde F, Heufelder M, Winter K, Schramm A. Autogenous bone grafts in oral implantology-is it still a "gold standard"? A consecutive review of 279 patients with 456 clinical procedures. Int J Implant Dent. 2017;3(1):23-.
Saleem M, Kaushik M, Ghai A, Tomar N, Singh S. Ligaplants: A Revolutionary Concept in Implant Dentistry. Ann Maxillofac Surg. 2020;10(1):195-7.
Sam G, Pillai BR. Evolution of Barrier Membranes in Periodontal Regeneration-"Are the third Generation Membranes really here?". J Clin Diagn Res. 2014;8(12):Ze14-7.
Seciu A-M, Craciunescu O, Zarnescu O. Advanced Regenerative Techniques Based on Dental Pulp Stem Cells for the Treatment of Periodontal Disease. 2019.
Shibuya N, Jupiter DC. Bone graft substitute: allograft and xenograft. Clin Podiatr Med Surg. 2015;32(1):21-34.
Takeda K, Shiba H, Mizuno N, Hasegawa N, Mouri Y, Hirachi A, et al. Brain-derived neurotrophic factor enhances periodontal tissue regeneration. Tissue Eng. 2005;11(9-10):1618-29.
Taylor DA. Cells for the treatment, prevention, and cure of cardiovascular disease. Tex Heart Inst J. 2009;36(2):148-9.
Thakare K, Bhongade ML, Charde P, Jaiswal P, Shah N, Deshpande A. Periodontal regeneration using platelet-derived growth factor in infrabony defects: a series of three cases. Case Rep Dent. 2013;2013:849823-.
Wadhawan A, Gowda TM, Mehta DS. Gore-tex(®) versus resolut adapt(®) GTR membranes with perioglas(®) in periodontal regeneration. Contemp Clin Dent. 2012;3(4):406-11.
Wang X, Chen J, Tian W. Strategies of cell and cell-free therapies for periodontal regeneration: the state of the art. Stem Cell Research & Therapy. 2022;13(1):536.
Webber MJ, Khan OF, Sydlik SA, Tang BC, Langer R. A perspective on the clinical translation of scaffolds for tissue engineering. Ann Biomed Eng. 2015;43(3):641-56.
Windisch P, Orban K, Salvi GE, Sculean A, Molnar B. Vertical-guided bone regeneration with a titanium-reinforced d-PTFE membrane utilizing a novel split-thickness flap design: a prospective case series. Clin Oral Investig. 2021;25(5):2969-80.
Yanagita M, Kojima Y, Kubota M, Mori K, Yamashita M, Yamada S, et al. Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells. Journal of dental research. 2014;93(1):89-95.
Yukna RA. Clinical human comparison of expanded polytetrafluoroethylene barrier membrane and freeze-dried dura mater allografts for guided tissue regeneration of lost periodontal support. I. Mandibular molar Class II furcations. J Periodontol. 1992;63(5):431-42.
Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Research & Therapy. 2019;10(1):68.
Zhao R, Yang R, Cooper PR, Khurshid Z, Shavandi A, Ratnayake J. Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules. 2021;26(10):3007.
Atala A. Regenerative medicine and tissue engineering in urology. Urol Clin North Am. 2009;36(2):199-209, viii-ix.
Fibbe WE. Mesenchymal stem cells. A potential source for skeletal repair. Ann Rheum Dis. 2002;61 Suppl 2(Suppl 2):ii29-31.
Fitzwater JL, Grande KB, Sailors JL, Acevedo JF, Word RA, Wai CY. Effect of myogenic stem cells on the integrity and histomorphology of repaired transected external anal sphincter. Int Urogynecol J. 2015;26(2):251-6.
Frigerio M, Milani R, Barba M, Locatelli L, Marino G, Donatiello G, et al. Single-incision slings for the treatment of stress urinary incontinence: efficacy and adverse effects at 10-year follow-up. Int Urogynecol J. 2021;32(1):187-91.
Hakim L, De Ridder D, Van der Aa F. Slings for urinary incontinence and the application of cell-based therapy. Adv Drug Deliv Rev. 2015;82-83:22-30.
Lee JY, Paik SY, Yuk SH, Lee JH, Ghil SH, Lee SS. Long term effects of muscle-derived stem cells on leak point pressure and closing pressure in rats with transected pudendal nerves. Mol Cells. 2004;18(3):309-13.
Manodoro S, Frigerio M, Barba M, Bosio S, de Vitis LA, Marconi AM. Stem Cells in Clinical Trials for Pelvic Floor Disorders: a Systematic Literature Review. Reprod Sci. 2022;29(6):1710-20.
Milani R, Frigerio M, Cola A, Beretta C, Spelzini F, Manodoro S. Outcomes of Transvaginal High Uterosacral Ligaments Suspension: Over 500-Patient Single-Center Study. Female Pelvic Med Reconstr Surg. 2018;24(3):203-6.
Palmieri S, Cola A, Ceccherelli A, Manodoro S, Frigerio M, Vergani P. Italian validation of the German Pelvic Floor Questionnaire for pregnant and postpartum women. Eur J Obstet Gynecol Reprod Biol. 2020;248:133-6.
Plair A, Bennington J, Williams JK, Parker-Autry C, Matthews CA, Badlani G. Regenerative medicine for anal incontinence: a review of regenerative therapies beyond cells. Int Urogynecol J. 2021;32(9):2337-47.
Schmid FA, Williams JK, Kessler TM, Stenzl A, Aicher WK, Andersson KE, et al. Treatment of Stress Urinary Incontinence with Muscle Stem Cells and Stem Cell Components: Chances, Challenges and Future Prospects. Int J Mol Sci. 2021;22(8).
Spelzini F, Manodoro S, Frigerio M, Nicolini G, Maggioni D, Donzelli E, et al. Stem cell augmented mesh materials: an in vitro and in vivo study. Int Urogynecol J. 2015;26(5):675-83.
Ulrich D, Edwards SL, Su K, Tan KS, White JF, Ramshaw JA, et al. Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair. Tissue Eng Part A. 2014;20(3-4):785-98.
Wright A, Arthaud-Day ML, Weiss ML. Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species. Front Cell Dev Biol. 2021;9:632717.
Wright B, Emmanuel A, Athanasakos E, Parmar N, Parker G, Green B, et al. Women's views on autologous cell-based therapy for post-obstetric incontinence. Regen Med. 2016;11(2):169-80.
Al-Ghadban S, Artiles M, Bunnell BA. Adipose Stem Cells in Regenerative Medicine: Looking Forward. Front Bioeng Biotechnol. 2021;9:837464.
Ali S, Haque N, Azhar Z, Saeinasab M, Sefat F. Regenerative Medicine of Liver: Promises, Advances and Challenges. Biomimetics (Basel). 2021;6(4).
Arjmand B, Goodarzi P, Mohamadi-Jahani F, Falahzadeh K, Larijani B. Personalized Regenerative Medicine. Acta Med Iran. 2017;55(3):144-9.
Armstrong JPK, Keane TJ, Roques AC, Patrick PS, Mooney CM, Kuan WL, et al. A blueprint for translational regenerative medicine. Sci Transl Med. 2020;12(572).
Arutyunyan IV, Fatkhudinov TK, Makarov AV, Elchaninov AV, Sukhikh GT. Regenerative medicine of pancreatic islets. World J Gastroenterol. 2020;26(22):2948-66.
Ashraf SS, Hosseinpour Sarmadi V, Larijani G, Naderi Garahgheshlagh S, Ramezani S, Moghadamifar S, et al. Regenerative medicine improve neurodegenerative diseases. Cell Tissue Bank. 2022.
Bei Y, Wang F, Yang C, Xiao J. Telocytes in regenerative medicine. J Cell Mol Med. 2015;19(7):1441-54.
Bellei B, Papaccio F, Picardo M. Regenerative Medicine-Based Treatment for Vitiligo: An Overview. Biomedicines. 2022;10(11).
Bellet P, Gasparotto M, Pressi S, Fortunato A, Scapin G, Mba M, et al. Graphene-Based Scaffolds for Regenerative Medicine. Nanomaterials (Basel). 2021;11(2).
Beyer BA, Lairson LL. Promoting remyelination: A case study in regenerative medicine. Curr Opin Chem Biol. 2022;70:102201.
Bijukumar DR, McGeehan C, Mathew MT. Regenerative Medicine Strategies in Biomedical Implants. Curr Osteoporos Rep. 2018;16(3):236-45.
Boddu S, Hashim PW, Nia JK, Horowitz R, Farberg A, Goldenberg G. Regenerative medicine in cosmetic dermatology. Cutis. 2018;101(1):33-6.
Brokesh AM, Gaharwar AK. Inorganic Biomaterials for Regenerative Medicine. ACS Appl Mater Interfaces. 2020;12(5):5319-44.
Buisson EM, Jeong J, Kim HJ, Choi D. Regenerative Medicine of the Bile Duct: Beyond the Myth. Int J Stem Cells. 2019;12(2):183-94.
Burns TC, Quinones-Hinojosa A. Regenerative medicine for neurological diseases-will regenerative neurosurgery deliver? Bmj. 2021;373:n955.
Cai JY, Zhang L, Chen J, Chen SY. Kartogenin and Its Application in Regenerative Medicine. Curr Med Sci. 2019;39(1):16-20.
Carr BJ. Regenerative Medicine and Rehabilitation Therapy in the Canine. Vet Clin North Am Small Anim Pract. 2023;53(4):801-27.
Casamitjana J, Espinet E, Rovira M. Pancreatic Organoids for Regenerative Medicine and Cancer Research. Front Cell Dev Biol. 2022;10:886153.
Catoira MC, Fusaro L, Di Francesco D, Ramella M, Boccafoschi F. Overview of natural hydrogels for regenerative medicine applications. J Mater Sci Mater Med. 2019;30(10):115.
Chen C, Hu Z, Liu S, Tseng H. Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace. Expert opinion on biological therapy. 2012;12(5):593-608.
Chingale M, Zhu D, Cheng K, Huang K. Bioengineering Technologies for Cardiac Regenerative Medicine. Front Bioeng Biotechnol. 2021;9:681705.
Ciccocioppo R, Cantore A, Chaimov D, Orlando G. Regenerative medicine: the red planet for clinicians. Intern Emerg Med. 2019;14(6):911-21.
Dahlgren LA. Regenerative Medicine Therapies for Equine Wound Management. Vet Clin North Am Equine Pract. 2018;34(3):605-20.
Davies JA, Murray P, Wilm B. Regenerative medicine therapies: lessons from the kidney. Curr Opin Physiol. 2020;14:41-7.
Davis NF, Cunnane EM, Quinlan MR, Mulvihill JJ, Lawrentschuk N, Bolton DM, et al. Biomaterials and Regenerative Medicine in Urology. Adv Exp Med Biol. 2018;1107:189-98.
De Assuncao TM, Jalan-Sakrikar N, Huebert RC. Regenerative Medicine and the Biliary Tree. Semin Liver Dis. 2017;37(1):17-27.
de Coppi P, Loukogeorgakis S, Götherström C, David AL, Almeida-Porada G, Chan JKY, et al. Regenerative medicine: prenatal approaches. Lancet Child Adolesc Health. 2022;6(9):643-53.
De D, Karmakar P, Bhattacharya D. Stem Cell Aging and Regenerative Medicine. Adv Exp Med Biol. 2021;1326:11-37.
Dulak J, Szade K, Szade A, Nowak W, Józkowicz A. Adult stem cells: hopes and hypes of regenerative medicine. Acta Biochim Pol. 2015;62(3):329-37.
Edgar L, Pu T, Porter B, Aziz JM, La Pointe C, Asthana A, et al. Regenerative medicine, organ bioengineering and transplantation. Br J Surg. 2020;107(7):793-800.
Etulain J. Platelets in wound healing and regenerative medicine. Platelets. 2018;29(6):556-68.
García-Perdomo HA, Jurado-Penagos A. Application of regenerative medicine and 3d bioprinting in urology. Actas Urol Esp (Engl Ed). 2022;46(6):323-8.
Garriboli M, Radford A, Southgate J. Regenerative medicine in urology. Eur J Pediatr Surg. 2014;24(3):227-36.
Gee AP. Regulation of Regenerative Medicine Products. Adv Exp Med Biol. 2018;1098:189-98.
Goudarzi R, Dehpour AR, Partoazar A. Nanomedicine and regenerative medicine approaches in osteoarthritis therapy. Aging Clin Exp Res. 2022;34(10):2305-15.
Grimaudo MA, Concheiro A, Alvarez-Lorenzo C. Nanogels for regenerative medicine. J Control Release. 2019;313:148-60.
Gu X, Carroll Turpin MA, Romero-Ortega MI. Biomaterials and Regenerative Medicine in Pain Management. Curr Pain Headache Rep. 2022;26(7):533-41.
Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019;8(8).
Head PL. Rehabilitation Considerations in Regenerative Medicine. Phys Med Rehabil Clin N Am. 2016;27(4):1043-54.
Hermerén G. The ethics of regenerative medicine. Biol Futur. 2021;72(2):113-8.
Hosseini S, Taghiyar L, Safari F, Baghaban Eslaminejad M. Regenerative Medicine Applications of Mesenchymal Stem Cells. Adv Exp Med Biol. 2018;1089:115-41.
Huang Y, Miyamoto D, Hidaka M, Adachi T, Gu WL, Eguchi S. Regenerative medicine for the hepatobiliary system: A review. J Hepatobiliary Pancreat Sci. 2021;28(11):913-30.
Imran SAM, MHA MH, Khairul Bariah AAN, Wan Kamarul Zaman WS, Nordin F. Regenerative Medicine Therapy in Malaysia: An Update. Front Bioeng Biotechnol. 2022;10:789644.
Jahani M, Rezazadeh D, Mohammadi P, Abdolmaleki A, Norooznezhad A, Mansouri K. Regenerative Medicine and Angiogenesis; Challenges and Opportunities. Adv Pharm Bull. 2020;10(4):490-501.
Jeyaraman M, Muthu S, Sharma S, Ganta C, Ranjan R, Jha SK. Nanofat: A therapeutic paradigm in regenerative medicine. World J Stem Cells. 2021;13(11):1733-46.
Jones BC, Shibuya S, Durkin N, De Coppi P. Regenerative medicine for childhood gastrointestinal diseases. Best Pract Res Clin Gastroenterol. 2022;56-57:101769.
Kanematsu A. Regenerative medicine for urological tissues: Updated review 2018. Int J Urol. 2018;25(9):788-91.
Kanetaka K, Eguchi S. Regenerative medicine for the upper gastrointestinal tract. Regen Ther. 2020;15:129-37.
Kanetaka K, Kobayashi S, Eguchi S. Regenerative medicine for the esophagus. Surg Today. 2018;48(8):739-47.
Kent I, Freund MR, Agarwal S, Wexner SD. The application of regenerative medicine in colorectal surgery. Surgery. 2022;171(4):867-72.
Kim HY, Kwon S, Um W, Shin S, Kim CH, Park JH, et al. Functional Extracellular Vesicles for Regenerative Medicine. Small. 2022;18(36):e2106569.
Kolios G, Moodley Y. Introduction to stem cells and regenerative medicine. Respiration. 2013;85(1):3-10.
Kuang J, Huang T, Pei D. The Art of Reprogramming for Regenerative Medicine. Front Cell Dev Biol. 2022;10:927555.
Lagasse E, Shizuru JA, Uchida N, Tsukamoto A, Weissman IL. Toward regenerative medicine. Immunity. 2001;14(4):425-36.
Lapteva L, Vatsan R, Purohit-Sheth T. Regenerative Medicine Therapies for Rare Diseases. Transl Sci Rare Dis. 2018;3(3-4):121-32.
Lehmann M, Königshoff M. Regenerative Medicine and the Hope for a Cure. Clin Chest Med. 2021;42(2):365-73.
Lerman LO. Cell-based regenerative medicine for renovascular disease. Trends Mol Med. 2021;27(9):882-94.
Li M, Fang F, Sun M, Zhang Y, Hu M, Zhang J. Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine. Theranostics. 2022;12(11):4879-903.
Little MH, Kairath P. Regenerative medicine in kidney disease. Kidney Int. 2016;90(2):289-99.
Marques Azzini GO, Marques Azzini VO, Santos GS, Visoni S, Fusco MA, Beker NS, et al. Cannabidiol for musculoskeletal regenerative medicine. Exp Biol Med (Maywood). 2023;248(5):445-55.
Matveyenko A, Vella A. Regenerative medicine in diabetes. Mayo Clin Proc. 2015;90(4):546-54.
McEwan JK, Tribe HC, Jacobs N, Hancock N, Qureshi AA, Dunlop DG, et al. Regenerative medicine in lower limb reconstruction. Regen Med. 2018;13(4):477-90.
Moioli EK, Bolotin D, Alam M. Regenerative Medicine and Stem Cells in Dermatology. Dermatol Surg. 2017;43(5):625-34.
Moradi SZ, Jalili F, Hoseinkhani Z, Mansouri K. Regenerative Medicine and Angiogenesis; Focused on Cardiovascular Disease. Adv Pharm Bull. 2022;12(4):686-99.
Mou X, Wu Q, Zhang Z, Liu Y, Zhang J, Zhang C, et al. Nanozymes for Regenerative Medicine. Small Methods. 2022;6(11):e2200997.
Mysore V, Alexander S, Nepal S, Venkataram A. Regenerative Medicine Treatments for Androgenetic Alopecia. Indian J Plast Surg. 2021;54(4):514-20.
National Academy of S. Regenerative Medicine. Washington (DC): National Academies Press (US)
Copyright © National Academy of Sciences.; 2003.
Nii T, Katayama Y. Biomaterial-Assisted Regenerative Medicine. Int J Mol Sci. 2021;22(16).
Nilforoushzadeh MA, Sisakht MM, Seifalian AM, Amirkhani MA, Banafshe HR, Verdi J, et al. Regenerative Medicine Applications in Wound Care. Curr Stem Cell Res Ther. 2017;12(8):658-74.
O'Neill JD, Pinezich MR, Guenthart BA, Vunjak-Novakovic G. Gut bioengineering strategies for regenerative medicine. Am J Physiol Gastrointest Liver Physiol. 2021;320(1):G1-g11.
Oie Y, Nishida K. Regenerative medicine for the cornea. Biomed Res Int. 2013;2013:428247.
Oie Y, Nishida K. Corneal regenerative medicine. Regen Ther. 2016;5:40-5.
Petrosyan A, Martins PN, Solez K, Uygun BE, Gorantla VS, Orlando G. Regenerative medicine applications: An overview of clinical trials. Front Bioeng Biotechnol. 2022;10:942750.
Petrosyan A, Montali F, Peloso A, Citro A, Byers LN, La Pointe C, et al. Regenerative medicine technologies applied to transplant medicine. An update. Front Bioeng Biotechnol. 2022;10:1015628.
Popowski K, Lutz H, Hu S, George A, Dinh PU, Cheng K. Exosome therapeutics for lung regenerative medicine. J Extracell Vesicles. 2020;9(1):1785161.
Rajabzadeh N, Fathi E, Farahzadi R. Stem cell-based regenerative medicine. Stem Cell Investig. 2019;6:19.
Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases. Animals (Basel). 2021;11(1).
Rose LF, Wolf EJ, Brindle T, Cernich A, Dean WK, Dearth CL, et al. The convergence of regenerative medicine and rehabilitation: federal perspectives. NPJ Regen Med. 2018;3:19.
Simoni E, Orsini G, Chicca M, Bettini S, Franceschini V, Martini A, et al. Regenerative medicine in hearing recovery. Cytotherapy. 2017;19(8):909-15.
Sittadjody S, Criswell T, Jackson JD, Atala A, Yoo JJ. Regenerative Medicine Approaches in Bioengineering Female Reproductive Tissues. Reprod Sci. 2021;28(6):1573-95.
Somuncu Ö S. Decellularization Concept in Regenerative Medicine. Adv Exp Med Biol. 2020;1212:71-85.
Tam PKH, Wong KKY, Atala A, Giobbe GG, Booth C, Gruber PJ, et al. Regenerative medicine: postnatal approaches. Lancet Child Adolesc Health. 2022;6(9):654-66.
Tang X, Qin H, Gu X, Fu X. China's landscape in regenerative medicine. Biomaterials. 2017;124:78-94.
Terzic A, Nelson TJ. Regenerative medicine primer. Mayo Clin Proc. 2013;88(7):766-75.
Terzic A, Pfenning MA, Gores GJ, Harper CM, Jr. Regenerative Medicine Build-Out. Stem Cells Transl Med. 2015;4(12):1373-9.
Van Bellinghen X, Idoux-Gillet Y, Pugliano M, Strub M, Bornert F, Clauss F, et al. Temporomandibular Joint Regenerative Medicine. Int J Mol Sci. 2018;19(2).
Verma S, Domb AJ, Kumar N. Nanomaterials for regenerative medicine. Nanomedicine (Lond). 2011;6(1):157-81.
Vijayavenkataraman S, Yan WC, Lu WF, Wang CH, Fuh JYH. 3D bioprinting of tissues and organs for regenerative medicine. Adv Drug Deliv Rev. 2018;132:296-332.
Wang Q, Stern JH, Temple S. Regenerative Medicine: Solution in Sight. Adv Exp Med Biol. 2016;854:543-8.
Waters SL, Schumacher LJ, El Haj AJ. Regenerative medicine meets mathematical modelling: developing symbiotic relationships. NPJ Regen Med. 2021;6(1):24.
Wormald JC, Fishman JM, Juniat S, Tolley N, Birchall MA. Regenerative medicine in otorhinolaryngology. J Laryngol Otol. 2015;129(8):732-9.
Wyles SP, Hayden RE, Meyer FB, Terzic A. Regenerative medicine curriculum for next-generation physicians. NPJ Regen Med. 2019;4:3.
Yamada S, Behfar A, Terzic A. Regenerative medicine clinical readiness. Regen Med. 2021;16(3):309-22.
Yasuhara T, Kameda M, Agari T, Date I. Regenerative medicine for Parkinson's disease. Neurol Med Chir (Tokyo). 2015;55(2):113-23.
Yu Y, Alkhawaji A, Ding Y, Mei J. Decellularized scaffolds in regenerative medicine. Oncotarget. 2016;7(36):58671-83.
Yuan AE, Pineda R. Regenerative medicine in Fuchs' endothelial corneal dystrophy. Taiwan J Ophthalmol. 2021;11(2):122-31.
Yuasa S, Fukuda K. Cardiac regenerative medicine. Circ J. 2008;72 Suppl A:A49-55.
Zhang C, Murphy SV, Atala A. Regenerative medicine in urology. Semin Pediatr Surg. 2014;23(3):106-11.
Taheri F, Rahmani E, Fard SS, Rezaei M, Ayati A, Farhoudian A, et al. Aging Process and Related Diseases. Kindle. 2023;3(1):1-117.
Farrokhi M, Rigi A, Mangouri A, Fadaei M, Shabani E, Mashouf P, et al. Role of Antioxidants in Autoimmune Diseases. Kindle. 2021;1(1):1-107.
Ghalamkarpour N, Fard AM, Babazadeh A, Nikseresht H, Feyzmanesh A, Soltani R, et al. Role of Biomarkers in Risk, Diagnosis, Response to Treatment, and Prognosis of the Autoimmune Diseases. Kindle. 2022;2(1):1-124.
Ahadiat S-A, Kamrani K, Fard AM, Bagherianlemraski M, Rahimpour E, Jamali M, et al. Role of Blood Groups in Risk, Severity, Prognosis, and Response to Treatment of the Diseases. Kindle. 2022;2(1):1-130.
Ahadiat S-A, Atighi J, Forouhi M, Mashatan N, Ghahremaniyeh Z, Radmanesh M, et al. Diagnosis and Management of Complications of COVID-19. Kindle. 2022;2(1):1-113.
Farrokhi M, Vafaei S, Bidares M, Siami H, Rigi A, Hannaniyan M, et al. Diagnosis and Treatment of Manifestations of COVID-19. Kindle. 2021;1(1):1-170.
Yarmohammadi B, Rigi A, Sahebkar F, Ahadiat S-A, Gharei F, Heydarian P, et al. Guidelines for Providing Services in Medical Departments During the COVID-19 Pandemic. Kindle. 2022;2(1):1-193.
Ahadiat S-A, Ghazalgoo A, Abadi SAH, Falaverjani HG, Bagherianlemraski M, Namazifar F, et al. Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases. Kindle. 2022;2(1):1-119.
Fard AM, Nikbakht T, Babaei N, Pouyamanesh M, Afzalian A, Kharazmkia A, et al. Role of Medicinal Plants in Treatment of Inflammatory Diseases. Kindle. 2022;2(1):1-139.
Tabatabaei SOH, Moazamiyanfar R, Fard AM, Salemi MH, Masjedi MNK, Yazdani Y, et al. Academic Textbook: The Role of Melatonin in Pathogenesis and Treatment of Autoimmune Diseases. Kindle. 2023;3(1):1-126.
Amini N, Azimzadeh M, Dosar MD, Fard AM, Habibzadeh N, Yahyazadehjasour S, et al. Role of Microbiome, Infection, and Inflammation in Autoimmune Diseases. Kindle. 2023;3(1):1-102.
Ahadiat S-A, Barati R, Moghadam NS, Samami E, Ghiabi S, Alyari M, et al. Role of Oxidative Stress and Antioxidants in Malignancies. Kindle. 2022;2(1):1-122.
Abadi SAH, Atbaei R, Forouhi M, Falaverjani HG, Moazamiyanfar R, Rezaei M, et al. Preventive and Therapeutic Approaches in Medical Departments During the COVID-19 Pandemic. Kindle. 2022;2(1):1-216.
Poudineh M, Poudineh S, Hosseini Z, Pouramini S, Fard SS, Fadavian H, et al. Risk Factors for the Development of Cancers. Kindle. 2023;3(1):1-118.
Rahmani E, Fard AM, Baghsheikhi H, Hosseini Z, Mashaollahi A, Atighi J, et al. Role of Selenium in Pathogenesis and Treatment of the Autoimmune Diseases. Kindle. 2022;2(1):1-131.
Ahadiat S-A, Falaverjani HG, Shabani M, Abadi SAH, Moazamiyanfar R, Rajabi SK, et al. The Role of Stem Cells in Treatment of Autoimmune Diseases. Kindle. 2022;2(1):1-136.
Ahadiat S-A, Shirazinia M, Shirazinia S, Garousi S, Mottahedi M, Jalali AB, et al. Role of Telemedicine in Management of Patients During the COVID-19 Pandemic. Kindle. 2022;2(1):1-191.
Poudineh S, Poudineh M, Roohinezhad R, Khorram R, Fard AM, Barzegar F, et al. Role of Vitamins in Pathogenesis and Treatment of Cancers. Kindle. 2023;3(1):1-110.
Adamič N, Vengust M. Regenerative medicine in lung diseases: A systematic review. Front Vet Sci. 2023;10:1115708.
Ahamad N, Singh BB. Calcium channels and their role in regenerative medicine. World J Stem Cells. 2021;13(4):260-80.
Arjmand B, Rabbani Z, Soveyzi F, Tayanloo-Beik A, Rezaei-Tavirani M, Biglar M, et al. Advancement of Organoid Technology in Regenerative Medicine. Regen Eng Transl Med. 2023;9(1):83-96.
Basu J, Bertram TA. Regenerative medicine of the gastrointestinal tract. Toxicol Pathol. 2014;42(1):82-90.
Beetler DJ, Di Florio DN, Law EW, Groen CM, Windebank AJ, Peterson QP, et al. The evolving regulatory landscape in regenerative medicine. Mol Aspects Med. 2023;91:101138.
Blair NF, Frith TJR, Barbaric I. Regenerative Medicine: Advances from Developmental to Degenerative Diseases. Adv Exp Med Biol. 2017;1007:225-39.
Català P, Thuret G, Skottman H, Mehta JS, Parekh M, S ND, et al. Approaches for corneal endothelium regenerative medicine. Prog Retin Eye Res. 2022;87:100987.
Christ GJ, Saul JM, Furth ME, Andersson KE. The pharmacology of regenerative medicine. Pharmacol Rev. 2013;65(3):1091-133.
De Coppi P. Regenerative medicine for congenital malformations. J Pediatr Surg. 2013;48(2):273-80.
De Coppi P, Deprest J. Regenerative medicine solutions in congenital diaphragmatic hernia. Semin Pediatr Surg. 2017;26(3):171-7.
Ding X, Liu H, Fan Y. Graphene-Based Materials in Regenerative Medicine. Adv Healthc Mater. 2015;4(10):1451-68.
Fanaroff AC, Morrow V, Krucoff MW, Seltzer JH, Perin EC, Taylor DA, et al. A Path Forward for Regenerative Medicine. Circ Res. 2018;123(4):495-505.
Gianni-Barrera R, Di Maggio N, Melly L, Burger MG, Mujagic E, Gürke L, et al. Therapeutic vascularization in regenerative medicine. Stem Cells Transl Med. 2020;9(4):433-44.
Gurtner GC, Chapman MA. Regenerative Medicine: Charting a New Course in Wound Healing. Adv Wound Care (New Rochelle). 2016;5(7):314-28.
Häneke T, Sahara M. Progress in Bioengineering Strategies for Heart Regenerative Medicine. Int J Mol Sci. 2022;23(7).
Hosseinkhani H, Domb AJ, Sharifzadeh G, Nahum V. Gene Therapy for Regenerative Medicine. Pharmaceutics. 2023;15(3).
Imafuku A, Sjoqvist S. Extracellular Vesicle Therapeutics in Regenerative Medicine. Adv Exp Med Biol. 2021;1312:131-8.
Kemp P. Regenerative medicine: looking backward 10 years further on. Regen Med. 2016;11(8):787-800.
Khang D, Carpenter J, Chun YW, Pareta R, Webster TJ. Nanotechnology for regenerative medicine. Biomed Microdevices. 2010;12(4):575-87.
Klosterhoff BS, Tsang M, She D, Ong KG, Allen MG, Willett NJ, et al. Implantable Sensors for Regenerative Medicine. J Biomech Eng. 2017;139(2):0210091-02100911.
Kubinová S, Syková E. Nanotechnologies in regenerative medicine. Minim Invasive Ther Allied Technol. 2010;19(3):144-56.
Lee JY, Kim HS. Extracellular Vesicles in Regenerative Medicine: Potentials and Challenges. Tissue Eng Regen Med. 2021;18(4):479-84.
Lesizza P, Aleksova A, Ortis B, Beltrami AP, Giacca M, Sinagra G. Regenerative Medicine and Biomarkers for Dilated Cardiomyopathy. In: Sinagra G, Merlo M, Pinamonti B, editors. Dilated Cardiomyopathy: From Genetics to Clinical Management. Cham (CH): Springer Copyright 2019, The Author(s). 2019. p. 173-85.
Mahdavi SS, Abdekhodaie MJ, Mashayekhan S, Baradaran-Rafii A, Djalilian AR. Bioengineering Approaches for Corneal Regenerative Medicine. Tissue Eng Regen Med. 2020;17(5):567-93.
Mao AS, Mooney DJ. Regenerative medicine: Current therapies and future directions. Proc Natl Acad Sci U S A. 2015;112(47):14452-9.
National Academies of Sciences E, Medicine, Health, Medicine D, Board on Health Sciences P, Forum on Regenerative M. The National Academies Collection: Reports funded by National Institutes of Health. In: Beachy SH, Nicholson A, Teferra L, Hackmann M, Addie S, editors. Applying Systems Thinking to Regenerative Medicine: Proceedings of a Workshop. Washington (DC): National Academies Press (US) Copyright 2021 by the National Academy of Sciences. All rights reserved.; 2021.
Orlando G, Soker S, Stratta RJ, Atala A. Will regenerative medicine replace transplantation? Cold Spring Harb Perspect Med. 2013;3(8).
Osafune K. iPSC technology-based regenerative medicine for kidney diseases. Clin Exp Nephrol. 2021;25(6):574-84.
Rayat Pisheh H, Ansari M, Eslami H. How is mechanobiology involved in bone regenerative medicine? Tissue Cell. 2022;76:101821.
Roy A, Mantay M, Brannan C, Griffiths S. Placental Tissues as Biomaterials in Regenerative Medicine. Biomed Res Int. 2022;2022:6751456.
Schwab R, Lim R, Goldberg R. Resolving intestinal fibrosis through regenerative medicine. Curr Opin Pharmacol. 2019;49:90-4.
Selvakumar PP, Rafuse MS, Johnson R, Tan W. Applying Principles of Regenerative Medicine to Vascular Stent Development. Front Bioeng Biotechnol. 2022;10:826807.
Shammaa R, El-Kadiry AE, Abusarah J, Rafei M. Mesenchymal Stem Cells Beyond Regenerative Medicine. Front Cell Dev Biol. 2020;8:72.
Sharma A, Clemens RA, Garcia O, Taylor DL, Wagner NL, Shepard KA, et al. Biomanufacturing in low Earth orbit for regenerative medicine. Stem Cell Reports. 2022;17(1):1-13.
Sharma A, Janus JR, Hamilton GS. Regenerative medicine and nasal surgery. Mayo Clin Proc. 2015;90(1):148-58.
Taylor DA, Sampaio LC, Ferdous Z, Gobin AS, Taite LJ. Decellularized matrices in regenerative medicine. Acta Biomater. 2018;74:74-89.
Vallet-Regi M, Salinas AJ. Mesoporous bioactive glasses for regenerative medicine. Mater Today Bio. 2021;11:100121.
Willadsen M, Chaise M, Yarovoy I, Zhang AQ, Parashurama N. Engineering molecular imaging strategies for regenerative medicine. Bioeng Transl Med. 2018;3(3):232-55.
Yang Z, Wu J. MicroRNAs and regenerative medicine. DNA Cell Biol. 2007;26(4):257-64.
Yeo DC, Wiraja C, Mantalaris A, Xu C. Nanosensors for regenerative medicine. J Biomed Nanotechnol. 2014;10(10):2722-46.
Yoshimi R, Nakajima H. Current State and Issues of Regenerative Medicine for Rheumatic Diseases. Front Med (Lausanne). 2022;9:813952.
Zakeri N, Mirdamadi ES, Kalhori D, Solati-Hashjin M. Signaling molecules orchestrating liver regenerative medicine. J Tissue Eng Regen Med. 2020;14(12):1715-37.
Abbas Mofrad H, Khalatbari J, Malihi Zakerini S, Mohammadi Shirmahalleh F, Shafti V. Analysis of Structural Equations in the Relationship of Marital Conflicts and Affective Security with Perceived Stress and Pregnancy Worries and Biological Indexes with the Mediation of Psychological Wellbeing in Pregnant Women. Women Studies. 2021;12(35):97-127.
Abbasmofrad H, Khalatbari J, Zakerini SM, Mohammadi Shir Mahalla F, Shafti V. Analysis of Structural Equations in Relation to Marital Conflicts and Emotional Security with Perceived Stress and Pregnancy Worries Mediated by Psychological Well-Being in Pregnant Women. MEJDS. 2022;12:140.
Zahir ST, Hesami M, Gharaeikhezri A, Rahmani K, Zare S, Shafiee M. The Evaluation of the recurrence and survival in patients with papillary thyroid cancer: A retrospective Study. Pakistan Journal of Medical and Health Sciences. 2021;15(3):1074-7.
Navabi N, Salehi A, ZAREI MR, Borna R. Pain experience after oral mucosal biopsy: A quasi-experimental study. 2012.
Ghaffari R, Salehi A, Salehi N. Comparison of second molar eruption pattern in skeletal class I and class III malocclusions among 8 9 years old children. Biomedical and Pharmacology Journal. 2015;8:811-6.
Mousavinasab SM, Salehi A, Salehi N. Effect of composite shade, curing time and mode on temperature rise of silorane and methacrylate-based composite resins. Caspian Journal of Dental Research. 2016;5(2):50-8.
Sadeghi M, Salehi A, Roberts M. Effect of chlorhexidine application on dentin bond strength durability of two etch-and-rinse adhesive versus a universal bond system. Journal of Dentistry and Oral Care Medicine. 2017;3(02):202.
Abbasi M, Sadeghi M, Salehi A. The Effect of Different Concentrations of Carbamide Peroxide Bleaching Gel on Shear Bond Strength of a Bonded Nanocomposite to Enamel and Dentin. Journal of Rafsanjan University of Medical Sciences. 2017;16(2).
Mousavinasab S-M, Atai M, Salehi N, Salehi A. Effect of shade and light curing mode on the degree of conversion of silorane-based and methacrylate-based resin composites. Journal of dental biomaterials. 2016;3(4):299.
