Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases
Keywords:
Vitamin D, , Pathogenesis,, Diagnosis, Treatment , Inflammatory DiseasesAbstract
Vitamin D performs its immunomodulatory effects on T lymphocytes, by inhibiting the synthesis of pro-inflammatory Th1 cytokines (IL-1, IL-2, IL-6, IL-12, IFN-γ, TNF-α, and TNF-β), and triggering the synthesis of anti-inflammatory regulatory Th2 cytokines (IL-4, IL-5, and IL-10).
Therefore, vitamin D potentiates the innate immune system and regulates the adaptive immune system, mainly by triggering the split to Th2 and regulatory T cells (Tregs), over the Th1 and Th17 lymphocytes differentiation, via direct and indirect effects on naive CD4+ cells. The general finding is an evident effect of switching capacity, from a pro-inflammatory autoimmune to an anti-inflammatory tolerogenic immunological effect.
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Published
2022-04-01
How to Cite
Ahadiat, S.-A., Ghazalgoo, A., Azizi Hassan Abadi, S., Ghasemi Falaverjani, H., Bagherianlemraski, M., Namazifar, F., Pourbagher Benam, S., Motioleslami, M., Sargazi Moghadam, N., Babashpour, S., Kazemi, F., Atighi, R., Mehrpouyan, A., Meftah, E., Salemi, M. H., Lotfi, H., Bitaraf, A., Khosravifar, M., Shafagh, S.-G., sharifi, R., Bemana, R., Yadollahifarsani, S., Soleimani, P., Ghafarzadeh, S., Sajedi Shacker, M., Mashatan, N., Shavakhi, M., Khodadadiyan, A., Ahmadian, S., Shirdel, E., Ghebleh, A., Javanshir, S., Shahi, S., Ahmadi Beni, M., Kiani, M., Poursaravani, F., Hematian, S., Jafari, D., & Taheri, F. (2022). Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases. Kindle, 2(1), 1–119. Retrieved from http://preferpub.org/index.php/kindle/article/view/Book7
