Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases

Authors

  • Seyed-Amirabbas Ahadiat
  • Arezoo Ghazalgoo
  • Saeme Azizi Hassan Abadi
  • Hajar Ghasemi Falaverjani
  • Mobina Bagherianlemraski
  • Farzaneh Namazifar
  • Sasan Pourbagher Benam
  • Moein Motioleslami
  • Nasibeh Sargazi Moghadam
  • Sevil Babashpour
  • Fatemeh Kazemi
  • Ramin Atighi
  • Afsaneh Mehrpouyan
  • Elahe Meftah
  • Mohammad Hossein Salemi
  • Hamed Lotfi
  • Ali Bitaraf
  • Mina Khosravifar
  • Seyyed-Ghavam Shafagh
  • Roya sharifi
  • Reza Bemana
  • Sepideh Yadollahifarsani
  • Parisa Soleimani
  • Saghi Ghafarzadeh
  • Mahdi Sajedi Shacker
  • Noushin Mashatan
  • Mitra Shavakhi
  • Alireza Khodadadiyan
  • Shahla Ahmadian
  • Elham Shirdel
  • Aida Ghebleh
  • Salar Javanshir
  • Shayan Shahi
  • Maryam Ahmadi Beni
  • Moein Kiani
  • Faranak Poursaravani
  • Saeid Hematian
  • Delaram Jafari
  • Fatemeh Taheri

Keywords:

Vitamin D, , Pathogenesis,, Diagnosis, Treatment , Inflammatory Diseases

Abstract

Vitamin D performs its immunomodulatory effects on T lymphocytes, by inhibiting the synthesis of pro-inflammatory Th1 cytokines (IL-1, IL-2, IL-6, IL-12, IFN-γ, TNF-α, and TNF-β), and triggering the synthesis of anti-inflammatory regulatory Th2 cytokines (IL-4, IL-5, and IL-10).
Therefore, vitamin D potentiates the innate immune system and regulates the adaptive immune system, mainly by triggering the split to Th2 and regulatory T cells (Tregs), over the Th1 and Th17 lymphocytes differentiation, via direct and indirect effects on naive CD4+ cells. The general finding is an evident effect of switching capacity, from a pro-inflammatory autoimmune to an anti-inflammatory tolerogenic immunological effect.

Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases

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Published

2022-04-01

How to Cite

Ahadiat, S.-A., Ghazalgoo, A., Azizi Hassan Abadi, S., Ghasemi Falaverjani, H., Bagherianlemraski, M., Namazifar, F., Pourbagher Benam, S., Motioleslami, M., Sargazi Moghadam, N., Babashpour, S., Kazemi, F., Atighi, R., Mehrpouyan, A., Meftah, E., Salemi, M. H., Lotfi, H., Bitaraf, A., Khosravifar, M., Shafagh, S.-G., sharifi, R., Bemana, R., Yadollahifarsani, S., Soleimani, P., Ghafarzadeh, S., Sajedi Shacker, M., Mashatan, N., Shavakhi, M., Khodadadiyan, A., Ahmadian, S., Shirdel, E., Ghebleh, A., Javanshir, S., Shahi, S., Ahmadi Beni, M., Kiani, M., Poursaravani, F., Hematian, S., Jafari, D., & Taheri, F. (2022). Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases. Kindle, 2(1), 1–119. Retrieved from https://preferpub.org/index.php/kindle/article/view/Book7

Issue

Vol. 2 No. 1 (2022): Book Series 2

Section

Scholarly Peer-reviewed Books

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