AI for Holistic Medicine: Understanding Multi-Organ Interactions in Cancers

Authors

  • Mehrdad Farrokhi
  • Saman Abdollahpour
  • Sanaz Amiri Marbini
  • Niloofar Taheri
  • Fatemeh Asadi
  • Saboura Sahebi
  • Oveis Ahmadzadeh
  • Farzaneh Khosravi
  • Kiana Bahmanipour
  • Kimia Kowsari
  • Atousa Ghorbani
  • Rahil GhorbaniNia
  • Nazanin Hashemi
  • Khalil Kalavani
  • Mohammad-Matin Karbalaee-Alinazari
  • Meisam Sargazi
  • Afshin Zarei
  • Zahra Sadin
  • Mahboobeh Majidnia
  • Sara Shokrollahi Yancheshmeh
  • Fatemeh Amini
  • Vahid Jafari
  • Atie Moghtadaei
  • Sara Montazeri Namin
  • Alireza Taheri
  • Maryam Houshmand Marvasti
  • Amin Sadeghnezhad
  • Atena Talebpoor Amirhandeh
  • Ali Aghajan

Keywords:

Artificial Intelligence, Holistic Medicine, Cancer

Abstract

Artificial intelligence (AI) is playing a major role in transforming holistic medicine, especially in cancer research and treatment. Traditionally, cancer was viewed as a disease that affects only one organ, such as the lungs, liver, or breast. However, recent scientific studies show that cancer is a complex disease involving interactions between multiple organs and biological systems. Tumors can influence the immune system, metabolism, hormones, blood circulation, and even distant organs through processes such as inflammation and metastasis. AI helps researchers and doctors understand these complicated connections more efficiently and accurately. One of the most important contributions of AI in holistic cancer medicine is its ability to analyze massive amounts of medical and biological data. Modern healthcare generates information from genomic sequencing, laboratory tests, medical imaging, electronic health records, and wearable devices. AI systems, particularly machine learning and deep learning models, can process this data to identify hidden patterns that humans may not easily detect. By combining information from different biological layers, known as “multi-omics” data, AI provides a more complete understanding of how cancer develops and spreads throughout the body. AI is also improving precision medicine, where treatments are tailored to the unique characteristics of each patient. Different patients often respond differently to the same cancer therapy. AI models can predict which treatments, such as chemotherapy, immunotherapy, or targeted drugs, are most likely to work for specific patients based on their genetic and molecular profiles. This personalized approach reduces unnecessary side effects and improves treatment outcomes. Another important application is AI-assisted medical imaging. AI-powered tools can analyze CT scans, MRI scans, and PET scans with high accuracy to detect tumors, monitor disease progression, and identify early signs of metastasis. These systems help doctors understand how cancer affects surrounding tissues and distant organs, supporting a more holistic approach to treatment planning. Holistic medicine also considers lifestyle, nutrition, stress, environmental exposure, and the gut microbiome in cancer care. AI can integrate these factors with medical data to create personalized wellness and treatment plans. For example, wearable devices can track physical activity, sleep, and vital signs, while AI analyzes this information to monitor patient health continuously. Despite its potential, challenges remain, including data privacy concerns, algorithm bias, and the need for clinical validation. Some AI systems also lack transparency, making it difficult for doctors to understand how decisions are made. Nevertheless, AI continues to advance rapidly and is expected to revolutionize cancer care in the future. In conclusion, AI is helping holistic medicine move toward a more comprehensive understanding of cancer as a multi-organ and system-wide disease. By combining biological, clinical, and lifestyle data, AI supports earlier diagnosis, personalized treatments, and better patient outcomes, marking a significant step forward in modern healthcare.

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AI for Holistic Medicine: Understanding Multi-Organ Interactions in Cancers

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2026-05-12

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Farrokhi, M., Abdollahpour, S., Amiri Marbini, S., Taheri, N., Asadi, F., Sahebi, S., Ahmadzadeh, O., Khosravi, F., Bahmanipour, K., Kowsari, K., Ghorbani, A., GhorbaniNia, R., Hashemi, N., Kalavani, K., Karbalaee-Alinazari, M.-M., Sargazi, M., Zarei, A., Sadin, Z., Majidnia, M., Shokrollahi Yancheshmeh, S., Amini, F., Jafari, V., Moghtadaei, A., Montazeri Namin, S., Taheri, A., Houshmand Marvasti, M., Sadeghnezhad, A., Talebpoor Amirhandeh, A., & Aghajan, A. (2026). AI for Holistic Medicine: Understanding Multi-Organ Interactions in Cancers. Kindle, 6(1), 1–186. Retrieved from https://preferpub.org/index.php/kindle/article/view/Book67

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